Molecules (Sep 2013)

Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota (Meliaceae)

  • Milton M. Kanashiro,
  • William R. de Freitas,
  • Raimundo Braz-Filho,
  • Ivo J. C. Vieira,
  • Wagner da S. Terra,
  • Maria Conceiço M. Torres

DOI
https://doi.org/10.3390/molecules181012180
Journal volume & issue
Vol. 18, no. 10
pp. 12180 – 12191

Abstract

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Two novel protolimonoids, named lepidotrichilins A (1) and B (2), four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one (3), 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one (4), dysorone D (5), deoxy-flindissone (6), and the two steroids β-sitosterol (7) and stigmasterol (8) were identified in leaves of Trichilia lepidota subsp. schumanniana (Harms) T.D. Pennington. From wood the coumarin scopoletin (9) was isolated. The structures were established by NMR (1D 1H and 13C-NMR and 2D 1H-1H COSY, HMQC and HMBC), mass spectroscopy and infrared (IR) spectral data. The hexane and methanol extracts of the leaves, the protolimonoids lepidotrichilins A (1) and B (2) (IC50 42.7 µg mL−1) and the protolimonoid deoxy-flindissone (6; IC50 9.3 µgmL−1) exhibited significant cytotoxic activity against the MOLT-4 and U937 leukemic cell lines.

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