The Agglomeration Mechanism of Phenytoin (Antiepileptic) by a Novel Agglomerated Crystallization Technique

Abstract

Novel agglomerated crystallization techniques, i.e., neutralization and solvent change, methods, were devised in order to design phenytoin (antiepileptic), crystals so as to be directly compounded during their formulation. The proposed techniques could directly transform the fine precipitated crystals into free-flowing spherical agglomerates during crystallization. Agglomeration by neutralization and solvent change was described in terms of a random-coalescence model and a mixed model with layering, respectively. The micromeritic properties of the agglomerates, e.g. surface topography, particle density and mechanical strength, depended on the agglomeration mechanism. The consolidation of the agglomerates in the neutralization process was represented by a function of the agglomeration rate constants.