Mechanisms of Inhibitory Effects of Polysubstituted Pyrimidines on Prostaglandin E<sub>2</sub> Production

Affiliations

Zdeněk Zídek: Institute of Experimental Medicine, The Czech Academy of Sciences, 142 20 Prague, Czech Republic
Viktor Kolman: Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, 166 10 Prague, Czech Republic
Ondřej Baszczyňski: Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, 166 10 Prague, Czech Republic
Filip Kalčic: Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, 166 10 Prague, Czech Republic
Daniel Board: Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, 166 10 Prague, Czech Republic
Zlatko Janeba: Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, 166 10 Prague, Czech Republic

Abstract

The pyrimidine heterocycle represents an elemental structural motif of numerous drugs. [...]