Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications

Kota Tamada; Keita Fukumoto; Tsuyoshi Toya; Nobuhiro Nakai; Janak R. Awasthi; Shinji Tanaka; Shigeo Okabe; François Spitz; Fumihito Saitow; Hidenori Suzuki; Toru Takumi

doi:10.1038/s41467-021-24359-3

Nature Communications (Jul 2021)

Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications

Kota Tamada,
Keita Fukumoto,
Tsuyoshi Toya,
Nobuhiro Nakai,
Janak R. Awasthi,
Shinji Tanaka,
Shigeo Okabe,
François Spitz,
Fumihito Saitow,
Hidenori Suzuki,
Toru Takumi

Affiliations

Kota Tamada: RIKEN Brain Science Institute, Wako
Keita Fukumoto: RIKEN Brain Science Institute, Wako
Tsuyoshi Toya: RIKEN Brain Science Institute, Wako
Nobuhiro Nakai: RIKEN Brain Science Institute, Wako
Janak R. Awasthi: RIKEN Brain Science Institute, Wako
Shinji Tanaka: Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Bunkyo
Shigeo Okabe: Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Bunkyo
François Spitz: Department of Human Genetics, University of Chicago
Fumihito Saitow: Department of Pharmacology, Garduate School of Medicine, Nippon Medical School, Bunkyo
Hidenori Suzuki: Department of Pharmacology, Garduate School of Medicine, Nippon Medical School, Bunkyo
Toru Takumi: RIKEN Brain Science Institute, Wako

DOI: https://doi.org/10.1038/s41467-021-24359-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Duplication of chromosome 15q11-q13 is associated with autism spectrum disorder (ASD). Here, the authors show that in mice paternal Dup15q results in ASD-like neuronal and behavioural impairment driven by Necdin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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