Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

Abstract

This review explores the molecular mechanisms that may be responsible for mitochondrial retrograde signalling related metabolic reprogramming in cancer and host cells in the tumour microenvironment and provides a summary of recent updates with regard to the functional modulation of diverse cells in the tumour microenvironment.

Keywords

• mitochondria
• retrograde signalling
• metabolic reprogramming
• tumour microenvironment
• EMT