Surface modification of Nd3+ activated gadolinium core-shell nanospheres for near-infrared and magnetic resonance dual functional bioimaging system

Junyi Li; Junhong Duan; Yunjie Liao; Xiaohe Liu; Pengfei Rong; Gen Chen; Hao Wan; Renzhi Ma

Materials & Design (Aug 2023)

Surface modification of Nd3+ activated gadolinium core-shell nanospheres for near-infrared and magnetic resonance dual functional bioimaging system

Junyi Li,
Junhong Duan,
Yunjie Liao,
Xiaohe Liu,
Pengfei Rong,
Gen Chen,
Hao Wan,
Renzhi Ma

Affiliations

Junyi Li: School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, PR China
Junhong Duan: Department of Radiology, The Third Xiangya Hospital, Central South University, No. 172 Tongzipo Road, Changsha, Hunan 410013, PR China
Yunjie Liao: Department of Radiology, The Third Xiangya Hospital, Central South University, No. 172 Tongzipo Road, Changsha, Hunan 410013, PR China
Xiaohe Liu: School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, PR China; School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, PR China; Corresponding authors at: School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, PR China (X. Liu).
Pengfei Rong: Department of Radiology, The Third Xiangya Hospital, Central South University, No. 172 Tongzipo Road, Changsha, Hunan 410013, PR China; Corresponding authors at: School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, PR China (X. Liu).
Gen Chen: School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, PR China
Hao Wan: School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, PR China
Renzhi Ma: International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan; Corresponding authors at: School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, PR China (X. Liu).

Journal volume & issue: Vol. 232
p. 112132

Abstract

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Visualization techniques are effective tools in diagnosis and therapy for biomedical applications. Due to the unavoidable shortcomings of single optical or magnetic resonance imaging, the introduction of dual functional imaging system is of great significance. Herein a new Gd1-xNdx(CO3)OH@SiO2 core–shell nanostructure were developed to fulfill the corresponding demands. Uniform nanospheres were acquired with surface modification and coated with thickness tunable silica shells. The samples presented strong luminescence penetrating biological tissue, due to the wide spectral region covering NIR I & II window of Nd3+ under 808 nm laser excitation. On the other hand, distinct contrast enhancement could be viewed for in vitro and in vivo MRI trials, which generates from high paramagnetic relaxation of Gd3+ and well dispersibility caused by silica shells. Along with the non-toxicity proved by the low concentration of leaching Gd3+ and nice biocompatibility of silica coated nanospheres, it is a superior candidate for NIR and MRI dual functional imaging platform in biological applications.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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