Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Gaofeng Xiong; Rachel L. Stewart; Jie Chen; Tianyan Gao; Timothy L. Scott; Luis M. Samayoa; Kathleen O’Connor; Andrew N. Lane; Ren Xu

doi:10.1038/s41467-018-06893-9

Nature Communications (Oct 2018)

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Gaofeng Xiong,
Rachel L. Stewart,
Jie Chen,
Tianyan Gao,
Timothy L. Scott,
Luis M. Samayoa,
Kathleen O’Connor,
Andrew N. Lane,
Ren Xu

Affiliations

Gaofeng Xiong: UK Markey Cancer Center, University of Kentucky
Rachel L. Stewart: Department of Pathology and Laboratory Medicine, University of Kentucky
Jie Chen: UK Markey Cancer Center, University of Kentucky
Tianyan Gao: UK Markey Cancer Center, University of Kentucky
Timothy L. Scott: Center for Environmental and Systems Biochemistry, University of Kentucky
Luis M. Samayoa: Department of Pathology and Laboratory Medicine, University of Kentucky
Kathleen O’Connor: UK Markey Cancer Center, University of Kentucky
Andrew N. Lane: Center for Environmental and Systems Biochemistry, University of Kentucky
Ren Xu: UK Markey Cancer Center, University of Kentucky

DOI: https://doi.org/10.1038/s41467-018-06893-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Hyperactivation of HIF-1α is crucial in progression of triple-negative breast cancer, but how HIF-1α stability is maintained in a hypoxia-independent manner is unclear. Here, the authors show collagen prolyl-4-hydroylase 1 stabilises HIF-1α and is involved in chemoresistance in TNBC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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