Monitoring of the Sensitivity In Vivo of <i>Plasmodium falciparum</i> to Artemether-Lumefantrine in Mali

Modibo Diarra; Drissa Coulibaly; Amadou Tapily; Boureima Guindo; Koualy Sanogo; Diakalia Koné; Youssouf Koné; Karim Koné; Aboudramane Bathily; Oumar Yattara; Mahamadou A. Thera; Alassane Dicko; Abdoulaye A. Djimdé; Issaka Sagara

doi:10.3390/tropicalmed6010013

Tropical Medicine and Infectious Disease (Jan 2021)

Monitoring of the Sensitivity In Vivo of <i>Plasmodium falciparum</i> to Artemether-Lumefantrine in Mali

Modibo Diarra,
Drissa Coulibaly,
Amadou Tapily,
Boureima Guindo,
Koualy Sanogo,
Diakalia Koné,
Youssouf Koné,
Karim Koné,
Aboudramane Bathily,
Oumar Yattara,
Mahamadou A. Thera,
Alassane Dicko,
Abdoulaye A. Djimdé,
Issaka Sagara

Affiliations

Modibo Diarra: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Drissa Coulibaly: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Amadou Tapily: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Boureima Guindo: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Koualy Sanogo: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Diakalia Koné: National Malaria Control Program (PNLP-Mali), Bamako 223, Mali
Youssouf Koné: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Karim Koné: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Aboudramane Bathily: Populations Services International-Mali (PSI-Mali), Bamako E5397, Mali
Oumar Yattara: Populations Services International-Mali (PSI-Mali), Bamako E5397, Mali
Mahamadou A. Thera: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Alassane Dicko: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Abdoulaye A. Djimdé: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali
Issaka Sagara: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences Techniques and Technology of Bamako, Bamako BP 1805, Mali

DOI: https://doi.org/10.3390/tropicalmed6010013
Journal volume & issue: Vol. 6, no. 1
p. 13

Abstract

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In Mali, since 2007, artemether-lumefantrine has been the first choice against uncomplicated malaria. Despite its effectiveness, a rapid selection of markers of resistance to partner drugs has been documented. This work evaluated the treatment according to the World Health Organization’s standard 28-day treatment method. The primary endpoint was the clinical and parasitological response corrected by a polymerase chain reaction. It was more than 99.9 percent, the proportion of patients with anemia significantly decrease compared to baseline (p Plasmodium falciparum remains sensitive to artemether-lumefantrine in Mali.

Published in Tropical Medicine and Infectious Disease

ISSN: 2414-6366 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/tropicalmed

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