Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Teddy Grand; Sarah Abi Gerges; Mélissa David; Marco A. Diana; Pierre Paoletti

doi:10.1038/s41467-018-07236-4

Nature Communications (Nov 2018)

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Teddy Grand,
Sarah Abi Gerges,
Mélissa David,
Marco A. Diana,
Pierre Paoletti

Affiliations

Teddy Grand: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM
Sarah Abi Gerges: Institut de Biologie Paris-Seine (IBPS) Sorbonne Université, CNRS, INSERM, Neurosciences Paris-Seine (NPS)
Mélissa David: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM
Marco A. Diana: Institut de Biologie Paris-Seine (IBPS) Sorbonne Université, CNRS, INSERM, Neurosciences Paris-Seine (NPS)
Pierre Paoletti: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM

DOI: https://doi.org/10.1038/s41467-018-07236-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional GluN1/GluN3A receptors in the juvenile brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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