Journal of Anaesthesiology Clinical Pharmacology (Jan 2014)
Considerations in perioperative assessment of valproic acid coagulopathy
Abstract
Valproic acid (VPA) is one of the widely prescribed antiepileptic drugs in children with multiple indications. VPA-induced coagulopathy may occur and constitute a pharmacological and practical challenge affecting pre-operative evaluation and management of patients receiving VPA therapy. This review summarizes the different studies documenting the incidence, severity and available recommendations related to this adverse effect.
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