Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Oct 2017)

Abdominal Aortic Calcifications Influences the Systemic and Renal Hemodynamic Response to Renal Denervation in the DENERHTN (Renal Denervation for Hypertension) Trial

  • Pierre‐Yves Courand,
  • Helena Pereira,
  • Costantino Del Giudice,
  • Philippe Gosse,
  • Matthieu Monge,
  • Guillaume Bobrie,
  • Pascal Delsart,
  • Claire Mounier‐Vehier,
  • Pierre Lantelme,
  • Thierry Denolle,
  • Caroline Dourmap,
  • Jean Michel Halimi,
  • Xavier Girerd,
  • Patrick Rossignol,
  • Faiez Zannad,
  • Olivier Ormezzano,
  • Bernard Vaisse,
  • Daniel Herpin,
  • Jean Ribstein,
  • Beatrice Bouhanick,
  • Jean‐Jacques Mourad,
  • Emile Ferrari,
  • Gilles Chatellier,
  • Marc Sapoval,
  • Arshid Azarine,
  • Michel Azizi

DOI
https://doi.org/10.1161/JAHA.117.007062
Journal volume & issue
Vol. 6, no. 10

Abstract

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BackgroundThe DENERHTN (Renal Denervation for Hypertension) trial confirmed the efficacy of renal denervation (RDN) in lowering daytime ambulatory systolic blood pressure when added to standardized stepped‐care antihypertensive treatment (SSAHT) for resistant hypertension at 6 months. Methods and ResultsThis post hoc exploratory analysis assessed the impact of abdominal aortic calcifications (AAC) on the hemodynamic and renal response to RDN at 6 months. In total, 106 patients with resistant hypertension were randomly assigned to RDN plus SSAHT or to the same SSAHT alone (control group). Total AAC volume was measured, with semiautomatic software and blind to randomization, from the aortic hiatus to the iliac bifurcation using the prerandomization noncontrast abdominal computed tomography scans of 90 patients. Measurements were expressed as tertiles. The baseline‐adjusted difference in the change in daytime ambulatory systolic blood pressure from baseline to 6 months between the RDN and control groups was −10.1 mm Hg (P=0.0462) in the lowest tertile and −2.5 mm Hg (P=0.4987) in the 2 highest tertiles of AAC volume. Estimated glomerular filtration rate remained stable at 6 months for the patients in the lowest tertile of AAC volume who underwent RDN (+2.5 mL/min per 1.73 m2) but decreased in the control group (−8.0 mL/min per 1.73 m2, P=0.0148). In the 2 highest tertiles of AAC volume, estimated glomerular filtration rate decreased similarly in the RDN and control groups (P=0.2640). ConclusionsRDN plus SSAHT resulted in a larger decrease in daytime ambulatory systolic blood pressure than SSAHT alone in patients with a lower AAC burden than in those with a higher AAC burden. This larger decrease in daytime ambulatory systolic blood pressure was not associated with a decrease in estimated glomerular filtration rate. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01570777.

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