Nature Communications (Apr 2022)
Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression
- Thomas G. Paulson,
- Patricia C. Galipeau,
- Kenji M. Oman,
- Carissa A. Sanchez,
- Mary K. Kuhner,
- Lucian P. Smith,
- Kevin Hadi,
- Minita Shah,
- Kanika Arora,
- Jennifer Shelton,
- Molly Johnson,
- Andre Corvelo,
- Carlo C. Maley,
- Xiaotong Yao,
- Rashesh Sanghvi,
- Elisa Venturini,
- Anne-Katrin Emde,
- Benjamin Hubert,
- Marcin Imielinski,
- Nicolas Robine,
- Brian J. Reid,
- Xiaohong Li
Affiliations
- Thomas G. Paulson
- Division of Human Biology, Fred Hutchinson Cancer Research Center
- Patricia C. Galipeau
- Division of Human Biology, Fred Hutchinson Cancer Research Center
- Kenji M. Oman
- Division of Human Biology, Fred Hutchinson Cancer Research Center
- Carissa A. Sanchez
- Division of Human Biology, Fred Hutchinson Cancer Research Center
- Mary K. Kuhner
- Department of Genome Sciences, University of Washington
- Lucian P. Smith
- Department of Genome Sciences, University of Washington
- Kevin Hadi
- New York Genome Center (NYGC)
- Minita Shah
- New York Genome Center (NYGC)
- Kanika Arora
- New York Genome Center (NYGC)
- Jennifer Shelton
- New York Genome Center (NYGC)
- Molly Johnson
- New York Genome Center (NYGC)
- Andre Corvelo
- New York Genome Center (NYGC)
- Carlo C. Maley
- Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences, Arizona State University
- Xiaotong Yao
- New York Genome Center (NYGC)
- Rashesh Sanghvi
- New York Genome Center (NYGC)
- Elisa Venturini
- New York Genome Center (NYGC)
- Anne-Katrin Emde
- Variant Bio
- Benjamin Hubert
- New York Genome Center (NYGC)
- Marcin Imielinski
- New York Genome Center (NYGC)
- Nicolas Robine
- New York Genome Center (NYGC)
- Brian J. Reid
- Division of Human Biology, Fred Hutchinson Cancer Research Center
- Xiaohong Li
- Division of Human Biology, Fred Hutchinson Cancer Research Center
- DOI
- https://doi.org/10.1038/s41467-022-29767-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Barrett’s esophagus is a pre-malignant condition that can progress to esophageal cancer. Here, the authors carry out whole genome sequencing of samples from patients who did or did not progress to cancer and find that mutations in many genes occur regardless of progression status, but also find features associated with progressive disease.
