Frontiers in Neuroscience (Dec 2023)
Causal link between prefrontal cortex and EEG microstates: evidence from patients with prefrontal lesion
- Zongya Zhao,
- Zongya Zhao,
- Zongya Zhao,
- Zongya Zhao,
- Zongya Zhao,
- Xiangying Ran,
- Xiangying Ran,
- Xiangying Ran,
- Xiangying Ran,
- Shiyang Lv,
- Shiyang Lv,
- Shiyang Lv,
- Shiyang Lv,
- Junming Wang,
- Junming Wang,
- Junming Wang,
- Junming Wang,
- Mengyue Qiu,
- Mengyue Qiu,
- Mengyue Qiu,
- Mengyue Qiu,
- Chang Wang,
- Chang Wang,
- Chang Wang,
- Chang Wang,
- Yongtao Xu,
- Yongtao Xu,
- Yongtao Xu,
- Yongtao Xu,
- Xiao Guo,
- Xiao Guo,
- Xiao Guo,
- Xiao Guo,
- Zhixian Gao,
- Zhixian Gao,
- Zhixian Gao,
- Zhixian Gao,
- Junlin Mu,
- Yi Yu,
- Yi Yu,
- Yi Yu,
- Yi Yu
Affiliations
- Zongya Zhao
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Zongya Zhao
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Zongya Zhao
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Zongya Zhao
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Zongya Zhao
- The First Affiliated Hospital of Xinxiang Medical University, Weihui, China
- Xiangying Ran
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Xiangying Ran
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Xiangying Ran
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Xiangying Ran
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Shiyang Lv
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Shiyang Lv
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Shiyang Lv
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Shiyang Lv
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Junming Wang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Junming Wang
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Junming Wang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Junming Wang
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Mengyue Qiu
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Mengyue Qiu
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Mengyue Qiu
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Mengyue Qiu
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Chang Wang
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Chang Wang
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Chang Wang
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Chang Wang
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Yongtao Xu
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Yongtao Xu
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Yongtao Xu
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Yongtao Xu
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Xiao Guo
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Xiao Guo
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Xiao Guo
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Xiao Guo
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Zhixian Gao
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Zhixian Gao
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Zhixian Gao
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Zhixian Gao
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- Junlin Mu
- The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China
- Yi Yu
- School of Medical Engineering, Xinxiang Medical University, Xinxiang, China
- Yi Yu
- Engineering Technology Research Center of Neurosense and Control of Henan Province, Xinxiang, China
- Yi Yu
- Henan International Joint Laboratory of Neural Information Analysis and Drug Intelligent Design, Xinxiang, China
- Yi Yu
- Henan Engineering Research Center of Medical VR Intelligent Sensing Feedback, Xinxiang, China
- DOI
- https://doi.org/10.3389/fnins.2023.1306120
- Journal volume & issue
-
Vol. 17
Abstract
IntroductionAt present, elucidating the cortical origin of EEG microstates is a research hotspot in the field of EEG. Previous studies have suggested that the prefrontal cortex is closely related to EEG microstate C and D, but whether there is a causal link between the prefrontal cortex and microstate C or D remains unclear.MethodsIn this study, pretrial EEG data were collected from ten patients with prefrontal lesions (mainly located in inferior and middle frontal gyrus) and fourteen matched healthy controls, and EEG microstate analysis was applied.ResultsOur results showed that four classical EEG microstate topographies were obtained in both groups, but microstate C topography in patient group was obviously abnormal. Compared to healthy controls, the average coverage and occurrence of microstate C significantly reduced. In addition, the transition probability from microstate A to C and from microstate B to C in patient group was significantly lower than those of healthy controls.DiscussionThe above results demonstrated that the damage of prefrontal cortex especially inferior and middle frontal gyrus could lead to abnormalities in the spatial distribution and temporal dynamics of microstate C not D, showing that there is a causal link between the inferior and middle frontal gyrus and the microstate C. The significance of our findings lies in providing new evidence for elucidating the cortical origin of microstate C.
Keywords
