Nature Communications (May 2021)
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
- Luca Hensen,
- Patricia T. Illing,
- E. Bridie Clemens,
- Thi H. O. Nguyen,
- Marios Koutsakos,
- Carolien E. van de Sandt,
- Nicole A. Mifsud,
- Andrea T. Nguyen,
- Christopher Szeto,
- Brendon Y. Chua,
- Hanim Halim,
- Simone Rizzetto,
- Fabio Luciani,
- Liyen Loh,
- Emma J. Grant,
- Phillipa M. Saunders,
- Andrew G. Brooks,
- Steve Rockman,
- Tom C. Kotsimbos,
- Allen C. Cheng,
- Michael Richards,
- Glen P. Westall,
- Linda M. Wakim,
- Thomas Loudovaris,
- Stuart I. Mannering,
- Michael Elliott,
- Stuart G. Tangye,
- David C. Jackson,
- Katie L. Flanagan,
- Jamie Rossjohn,
- Stephanie Gras,
- Jane Davies,
- Adrian Miller,
- Steven Y. C. Tong,
- Anthony W. Purcell,
- Katherine Kedzierska
Affiliations
- Luca Hensen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Patricia T. Illing
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- E. Bridie Clemens
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Thi H. O. Nguyen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Marios Koutsakos
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Carolien E. van de Sandt
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Nicole A. Mifsud
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Andrea T. Nguyen
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Christopher Szeto
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Brendon Y. Chua
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Hanim Halim
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Simone Rizzetto
- School of Medical Sciences and The Kirby Institute, UNSW Sydney
- Fabio Luciani
- School of Medical Sciences and The Kirby Institute, UNSW Sydney
- Liyen Loh
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Emma J. Grant
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Phillipa M. Saunders
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Andrew G. Brooks
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Steve Rockman
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Tom C. Kotsimbos
- Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital
- Allen C. Cheng
- School of Public Health and Preventive Medicine, Monash University
- Michael Richards
- Victorian Infectious Diseases Service, The Royal Melbourne Hospital, and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Glen P. Westall
- Lung Transplant Unit, Alfred Hospital
- Linda M. Wakim
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Thomas Loudovaris
- Immunology and Diabetes Unit, St Vincent’s Institute of Medical Research
- Stuart I. Mannering
- Immunology and Diabetes Unit, St Vincent’s Institute of Medical Research
- Michael Elliott
- Sydney Medical School, University of Sydney
- Stuart G. Tangye
- Immunology Division, Garvan Institute of Medical Research
- David C. Jackson
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Katie L. Flanagan
- Tasmanian Vaccine Trial Centre, Launceston General Hospital
- Jamie Rossjohn
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Stephanie Gras
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Jane Davies
- Menzies School of Health Research
- Adrian Miller
- Indigenous Engagement, CQUniversity
- Steven Y. C. Tong
- Victorian Infectious Diseases Service, The Royal Melbourne Hospital, and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Anthony W. Purcell
- Department of Biochemistry and Molecular Biology & Infection and Immunity Program, Biomedicine Discovery Institute, Monash University
- Katherine Kedzierska
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- DOI
- https://doi.org/10.1038/s41467-021-23212-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:02 and validate immunodominance of some of these epitopes in mice.
