Frontiers in Public Health (Dec 2022)

Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study

  • Chun-Yen Huang,
  • Jia-In Lee,
  • Chia-Wen Chang,
  • Yao-Hua Liu,
  • Shu-Pin Huang,
  • Shu-Pin Huang,
  • Szu-Chia Chen,
  • Szu-Chia Chen,
  • Szu-Chia Chen,
  • Szu-Chia Chen,
  • Jiun-Hung Geng,
  • Jiun-Hung Geng,
  • Jiun-Hung Geng,
  • Jiun-Hung Geng

DOI
https://doi.org/10.3389/fpubh.2022.1029962
Journal volume & issue
Vol. 10

Abstract

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IntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts.MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed cataracts was examined in a cross-sectional cohort and was validated in a longitudinal cohort of 25,263 participants without cataracts at baseline.Results and discussionOf all participants, cataracts occurred in 503/1,947 (26%) and 10,464/119,433 (9%) subjects in the CKD and non-CKD groups, respectively. Multivariate logistic regression showed that CKD was significantly associated with a higher prevalence of self-reported diagnosed cataracts. In the validation cohort, a higher incidence of cataracts was also noted in the CKD group (65/317, 21%) compared to the non-CKD group (1,964/24,252, 8%) during a mean 47-month follow-up. After adjusting for confounders, subjects with CKD had a 1.498-fold higher risk of incident cataracts than those without CKD (95% confidence interval = 1.114 to 2.013, p value = 0.007). We found that CKD was associated with a higher prevalence of cataracts as well as incident cataracts, which suggests CKD patients and their primary physicians should be aware of this disease and can provide a clue for further exploration of the possible mechanisms and treatments.

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