Nature Communications (May 2021)
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
- Wendan Ren,
- Huitao Fan,
- Sara A. Grimm,
- Jae Jin Kim,
- Linhui Li,
- Yiran Guo,
- Christopher James Petell,
- Xiao-Feng Tan,
- Zhi-Min Zhang,
- John P. Coan,
- Jiekai Yin,
- Dae In Kim,
- Linfeng Gao,
- Ling Cai,
- Nelli Khudaverdyan,
- Burak Çetin,
- Dinshaw J. Patel,
- Yinsheng Wang,
- Qiang Cui,
- Brian D. Strahl,
- Or Gozani,
- Kyle M. Miller,
- Seán E. O’Leary,
- Paul A. Wade,
- Gang Greg Wang,
- Jikui Song
Affiliations
- Wendan Ren
- Department of Biochemistry, University of California
- Huitao Fan
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Sara A. Grimm
- Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park
- Jae Jin Kim
- Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin
- Linhui Li
- Department of Biochemistry, University of California
- Yiran Guo
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Christopher James Petell
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Xiao-Feng Tan
- Department of Biochemistry, University of California
- Zhi-Min Zhang
- Department of Biochemistry, University of California
- John P. Coan
- Department of Biology, Stanford University
- Jiekai Yin
- Environmental Toxicology Graduate Program, University of California
- Dae In Kim
- Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin
- Linfeng Gao
- Environmental Toxicology Graduate Program, University of California
- Ling Cai
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Nelli Khudaverdyan
- Department of Biochemistry, University of California
- Burak Çetin
- Cell, Molecular, and Developmental Biology Graduate Program, University of California, Riverside
- Dinshaw J. Patel
- Structural Biology Program, Memorial Sloan Kettering Cancer Center
- Yinsheng Wang
- Environmental Toxicology Graduate Program, University of California
- Qiang Cui
- Departments of Chemistry, Physics and Biomedical Engineering, Boston University
- Brian D. Strahl
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Or Gozani
- Department of Biology, Stanford University
- Kyle M. Miller
- Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, Institute for Cellular and Molecular Biology, University of Texas at Austin
- Seán E. O’Leary
- Department of Biochemistry, University of California
- Paul A. Wade
- Division of Intramural Research, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park
- Gang Greg Wang
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
- Jikui Song
- Department of Biochemistry, University of California
- DOI
- https://doi.org/10.1038/s41467-021-22665-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.
