Nature Communications (Oct 2021)
Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance
- Yongli Qin,
- Lina Jia,
- Huijiao Liu,
- Wenqiang Ma,
- Xinmin Ren,
- Haifeng Li,
- Yuanwu Liu,
- Haiwen Li,
- Shuoqian Ma,
- Mei Liu,
- Pingping Li,
- Jinghua Yan,
- Jiyan Zhang,
- Yangdong Guo,
- Hua You,
- Yan Guo,
- Nafis A. Rahman,
- Sławomir Wołczyński,
- Adam Kretowski,
- Dangsheng Li,
- Xiru Li,
- Fazheng Ren,
- Xiangdong Li
Affiliations
- Yongli Qin
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Lina Jia
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Huijiao Liu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Wenqiang Ma
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Xinmin Ren
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Haifeng Li
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yuanwu Liu
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Haiwen Li
- Agricultural Research Station, College of Agriculture, Virginia State University
- Shuoqian Ma
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Mei Liu
- Department of Pathology, Chinese PLA General Hospital
- Pingping Li
- Academy of Medical Sciences & Peking Union, Medical College
- Jinghua Yan
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
- Jiyan Zhang
- Department of Molecular Immunology, Institute of Basic Medical Sciences
- Yangdong Guo
- State Key Laboratory of the Agro-Biotechnology, College of Horticultural Science, China Agricultural University
- Hua You
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
- Yan Guo
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Nafis A. Rahman
- Department of Physiology, Institute of Biomedicine, University of Turku
- Sławomir Wołczyński
- Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok
- Adam Kretowski
- Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok
- Dangsheng Li
- Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Xiru Li
- Department of Surgery, Chinese PLA General Hospital
- Fazheng Ren
- Department of Nutrition and Human Health, China Agricultural University
- Xiangdong Li
- State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-021-26408-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Macrophage inflammation promotes insulin resistance during diet-induced obesity. Here the authors show that macrophage NOC4L is decreased in humans and mice with obesity, that macrophage NOC4L deficiency aggravated high-fat diet induced inflammation and insulin resistance, and that NOC4L interacts with toll-like receptor 4, to inhibit endocytosis, and thus blocks TLF4/TRIF inflammatory signaling.
