JACC: Case Reports (Jun 2023)
Inflammatory Fabry Cardiomyopathy Demonstrated Using Simultaneous [18F]-FDG PET-CMR
- Christopher Orsborne, MBChB,
- Jose M. Anton-Rodrigez, PhD,
- Neal Sherratt, BS,
- Amy Watkins, BS,
- Maelene Lohezic, PhD,
- David Clark, BSc,
- William Lloyd, PhD,
- Josephine H. Naish, PhD,
- Peter Woolfson, MD,
- Anna B. Reid, PhD,
- Matthias Schmitt, PhD,
- Sivakumar Muthu, MD,
- Parthiban Arumugam, MD,
- Ana Jovanovic, MD,
- Christopher A. Miller, PhD
Affiliations
- Christopher Orsborne, MBChB
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom; Salford Royal NHS Foundation Trust, Salford, United Kingdom
- Jose M. Anton-Rodrigez, PhD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
- Neal Sherratt, BS
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
- Amy Watkins, BS
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
- Maelene Lohezic, PhD
- GE Healthcare, Manchester, United Kingdom
- David Clark, BSc
- Manchester University NHS Foundation Trust, Manchester, United Kingdom
- William Lloyd, PhD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
- Josephine H. Naish, PhD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom
- Peter Woolfson, MD
- Salford Royal NHS Foundation Trust, Salford, United Kingdom
- Anna B. Reid, PhD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom
- Matthias Schmitt, PhD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom
- Sivakumar Muthu, MD
- Manchester University NHS Foundation Trust, Manchester, United Kingdom
- Parthiban Arumugam, MD
- Manchester University NHS Foundation Trust, Manchester, United Kingdom
- Ana Jovanovic, MD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Salford Royal NHS Foundation Trust, Salford, United Kingdom
- Christopher A. Miller, PhD
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom; Division of Cell-Matrix Biology & Regenerative Medicine, Wellcome Centre for Cell-Matrix Research, School of Biology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Address for correspondence: Prof Christopher A. Miller, Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
- Journal volume & issue
-
Vol. 15
p. 101863
Abstract
Using hybridized [18F]-fluorodeoxyglucose positron emission tomography with cardiac magnetic resonance, we identify active myocardial inflammation and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that late gadolinium enhancement represents, at least in part, active myocardial inflammation and identify an early inflammatory phenotype that may represent a therapeutic window before irreversible tissue injury and adaptation occur. (Level of Difficulty: Intermediate.)
