PHARMACOTERAPEUTIC POSSIBILITIES OF USING THE ANTAGONISTS OF THE SEROTONIN RECEPTORS IN THE VOMITING THERAPY

Abstract

Vomiting is a frequent symptom following diverse diagnostic and pharmacothcrapeulicprocedures. The knowledge of the anatomic-neurophysiological basis ofthis disorder represents the basis for a qualitative and adequate pharmacotherapy.The involvement of numerous neurotransmitters and neuromodulators in the mechanism of the appearance of nausea and vomiting creates the need for morethrough knowledge of these occurrences. The serotonin plays an important role in thecoordination of the impulses relevant for the emergence of vomiting both in thecentral and in the peripheral nervous system. The role of particular types, especiallyof the 5HT3 the serotonin receptors in the mechanism of the emergence of thesymptom is also proved. Due to all this the use of the selective antagonists of theserotonin receptors in today regarded as the ''golden standard" of antiemetic therapy.The paper tries lo present the experimentally-proved basis for the use of thismedication especially through a detailed description of the preclinic examination ofthe use of the selective antagonists of the serotonin receptors in the therapy ofincreased motility of the gastrointeslinal system and vomiting. Likewise, we havealso shown clinic proofs about efficient activity of this medicament in the postoperativevomiting therapy after various surgical interventions in total anesthesia.

Keywords

• Vomiting
• antagonists of the serotonin receptors