Nature Communications (May 2017)

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

  • Xiao Zhang,
  • Yongxia Qiao,
  • Qi Wu,
  • Yan Chen,
  • Shaowu Zou,
  • Xiangfan Liu,
  • Guoqing Zhu,
  • Yinghui Zhao,
  • Yuxin Chen,
  • Yongchun Yu,
  • Qiuhui Pan,
  • Jiayi Wang,
  • Fenyong Sun

DOI
https://doi.org/10.1038/ncomms15280
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.