Untailored vs. Gender- and Body-Mass-Index-Tailored Skeletal Muscle Mass Index (SMI) to Assess Sarcopenia in Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Cristina Morelli; Vincenzo Formica; Paolo Bossi; Michela Rofei; Simona Guerriero; Silvia Riondino; Renato Argirò; Noemi Pucci; Tonia Cenci; Luca Savino; Carla G. Rinaldi; Francesco Garaci; Augusto Orlandi; Rolando M. D’Angelillo; Hendrik-Tobias Arkenau; Mario Roselli

doi:10.3390/cancers15194716

Cancers (Sep 2023)

Untailored vs. Gender- and Body-Mass-Index-Tailored Skeletal Muscle Mass Index (SMI) to Assess Sarcopenia in Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Cristina Morelli,
Vincenzo Formica,
Paolo Bossi,
Michela Rofei,
Simona Guerriero,
Silvia Riondino,
Renato Argirò,
Noemi Pucci,
Tonia Cenci,
Luca Savino,
Carla G. Rinaldi,
Francesco Garaci,
Augusto Orlandi,
Rolando M. D’Angelillo,
Hendrik-Tobias Arkenau,
Mario Roselli

Affiliations

Cristina Morelli: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy
Vincenzo Formica: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy
Paolo Bossi: Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, “ASST Spedali Civili di Brescia”, University of Brescia, 25123 Brescia, Italy
Michela Rofei: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy
Simona Guerriero: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy
Silvia Riondino: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy
Renato Argirò: Interventional Radiology Unit, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
Noemi Pucci: Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
Tonia Cenci: Anatomic Pathology, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
Luca Savino: Anatomic Pathology, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
Carla G. Rinaldi: Radiation Oncology, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00152 Rome, Italy
Francesco Garaci: Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
Augusto Orlandi: Anatomic Pathology, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
Rolando M. D’Angelillo: Radiation Oncology, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00152 Rome, Italy
Hendrik-Tobias Arkenau: Ellipses Pharma, London W1J 8LG, UK
Mario Roselli: Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy

DOI: https://doi.org/10.3390/cancers15194716
Journal volume & issue: Vol. 15, no. 19
p. 4716

Abstract

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(1) Background: Sarcopenia lasting >1 year might be considered a chronic condition in many HNSCC patients. CT-scan-derived Skeletal Muscle Mass Index (SMI) is an established surrogate of sarcopenia; yet, the cut-off reported in the literature (literature-based, lb-SMI p p = 0.0004). (4) Conclusions: A tailored SMI assessment would improve clinical management of sarcopenia in chemoradiotherapy-, bio-chemotherapy- or chemo-immunotherapy-treated HNSCC patients. Gender-based SMI could be used for prognostication in HNSCC patients.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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