Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits

Bingxin Zhao; Yue Shan; Yue Yang; Zhaolong Yu; Tengfei Li; Xifeng Wang; Tianyou Luo; Ziliang Zhu; Patrick Sullivan; Hongyu Zhao; Yun Li; Hongtu Zhu

doi:10.1038/s41467-021-23130-y

Nature Communications (May 2021)

Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits

Bingxin Zhao,
Yue Shan,
Yue Yang,
Zhaolong Yu,
Tengfei Li,
Xifeng Wang,
Tianyou Luo,
Ziliang Zhu,
Patrick Sullivan,
Hongyu Zhao,
Yun Li,
Hongtu Zhu

Affiliations

Bingxin Zhao: Department of Biostatistics, University of North Carolina at Chapel Hill
Yue Shan: Department of Biostatistics, University of North Carolina at Chapel Hill
Yue Yang: Department of Biostatistics, University of North Carolina at Chapel Hill
Zhaolong Yu: Interdepartmental Program in Computational Biology and Bioinformatics, Yale University
Tengfei Li: Department of Radiology, University of North Carolina at Chapel Hill
Xifeng Wang: Department of Biostatistics, University of North Carolina at Chapel Hill
Tianyou Luo: Department of Biostatistics, University of North Carolina at Chapel Hill
Ziliang Zhu: Department of Biostatistics, University of North Carolina at Chapel Hill
Patrick Sullivan: Department of Genetics, University of North Carolina at Chapel Hill
Hongyu Zhao: Interdepartmental Program in Computational Biology and Bioinformatics, Yale University
Yun Li: Department of Biostatistics, University of North Carolina at Chapel Hill
Hongtu Zhu: Department of Biostatistics, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s41467-021-23130-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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