Nature Communications (Jul 2017)
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis
- Hyunjoo Cha-Molstad,
- Ji Eun Yu,
- Zhiwei Feng,
- Su Hyun Lee,
- Jung Gi Kim,
- Peng Yang,
- Bitnara Han,
- Ki Woon Sung,
- Young Dong Yoo,
- Joonsung Hwang,
- Terry McGuire,
- Sang Mi Shim,
- Hyun Dong Song,
- Srinivasrao Ganipisetti,
- Nuozhou Wang,
- Jun Min Jang,
- Min Jae Lee,
- Seung Jun Kim,
- Kyung Ho Lee,
- Jin Tae Hong,
- Aaron Ciechanover,
- Inhee Mook-Jung,
- Kwang Pyo Kim,
- Xiang-Qun Xie,
- Yong Tae Kwon,
- Bo Yeon Kim
Affiliations
- Hyunjoo Cha-Molstad
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- Ji Eun Yu
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- Zhiwei Feng
- Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh
- Su Hyun Lee
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Jung Gi Kim
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- Peng Yang
- Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh
- Bitnara Han
- Department of Applied Chemistry, College of Applied Science, Kyung Hee University
- Ki Woon Sung
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Young Dong Yoo
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Joonsung Hwang
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- Terry McGuire
- Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh
- Sang Mi Shim
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Hyun Dong Song
- Department of Biochemistry and Biomedical Science, Seoul National University College of Medicine
- Srinivasrao Ganipisetti
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- Nuozhou Wang
- Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh
- Jun Min Jang
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Min Jae Lee
- Department of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Seoul National University College of Medicine
- Seung Jun Kim
- Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology
- Kyung Ho Lee
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- Jin Tae Hong
- Department of Drug Discovery and Development, College of Pharmacy, Chungbuk National University
- Aaron Ciechanover
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Inhee Mook-Jung
- Department of Biochemistry and Biomedical Science, Seoul National University College of Medicine
- Kwang Pyo Kim
- Department of Applied Chemistry, College of Applied Science, Kyung Hee University
- Xiang-Qun Xie
- Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh
- Yong Tae Kwon
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine, Seoul National University
- Bo Yeon Kim
- World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology
- DOI
- https://doi.org/10.1038/s41467-017-00085-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targets these cargos to autophagosomal degradation.
