Proteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma

Abstract

Kaneko et al. compare the proteome and phosphoproteome of primary HPV + oropharyngeal squamous cell cancers with tumours that recurred following chemotherapy/radiation. The authors identify signatures of fibrosis, matrix remodeling, and epithelial-mesenchymal transition and reprogrammed cytoskeletal signalling in recurrent tumours.