Nature Communications (Oct 2022)
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system
- Andreas Weigert,
- Xiang Zheng,
- Alina Nenzel,
- Kati Turkowski,
- Stefan Günther,
- Elisabeth Strack,
- Evelyn Sirait-Fischer,
- Eiman Elwakeel,
- Ivan M. Kur,
- Vandana S. Nikam,
- Chanil Valasarajan,
- Hauke Winter,
- Alexander Wissgott,
- Robert Voswinkel,
- Friedrich Grimminger,
- Bernhard Brüne,
- Werner Seeger,
- Soni Savai Pullamsetti,
- Rajkumar Savai
Affiliations
- Andreas Weigert
- Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I
- Xiang Zheng
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Alina Nenzel
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Kati Turkowski
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Stefan Günther
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Elisabeth Strack
- Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I
- Evelyn Sirait-Fischer
- Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I
- Eiman Elwakeel
- Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I
- Ivan M. Kur
- Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I
- Vandana S. Nikam
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Chanil Valasarajan
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Hauke Winter
- Translational Lung Research Center (TLRC), Member of the DZL; Department of Thoracic Surgery, Thorax klinik at the University Hospital Heidelberg
- Alexander Wissgott
- Department of Internal Medicine, Justus-Liebig University Giessen, Member of the DZL, Member of CPI
- Robert Voswinkel
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Friedrich Grimminger
- Department of Internal Medicine, Justus-Liebig University Giessen, Member of the DZL, Member of CPI
- Bernhard Brüne
- Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I
- Werner Seeger
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Soni Savai Pullamsetti
- Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)
- Rajkumar Savai
- Frankfurt Cancer Institute (FCI), Goethe University, and German Cancer Consortium (DKTK), Partner Site Frankfurt
- DOI
- https://doi.org/10.1038/s41467-022-33458-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate microenvironmental niche and sensitivity to endothelin blockade.
