Nature Communications (May 2019)
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
- Roberto Lande,
- Ernest Y. Lee,
- Raffaella Palazzo,
- Barbara Marinari,
- Immacolata Pietraforte,
- Giancarlo Santiago Santos,
- Yves Mattenberger,
- Francesca Spadaro,
- Katia Stefanantoni,
- Nicoletta Iannace,
- Aleksandra Maria Dufour,
- Mario Falchi,
- Manuela Bianco,
- Elisabetta Botti,
- Luca Bianchi,
- Montserrat Alvarez,
- Valeria Riccieri,
- Marie-Elise Truchetet,
- Gerard C.L. Wong,
- Carlo Chizzolini,
- Loredana Frasca
Affiliations
- Roberto Lande
- National Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)
- Ernest Y. Lee
- Department of Bioengineering, Department of Chemistry & Biochemistry, and California NanoSystems Institute, University of California
- Raffaella Palazzo
- National Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)
- Barbara Marinari
- Dermatology Unit, Department of Systems Medicine, University of Tor Vergata
- Immacolata Pietraforte
- Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità
- Giancarlo Santiago Santos
- Department of Bioengineering, Department of Chemistry & Biochemistry, and California NanoSystems Institute, University of California
- Yves Mattenberger
- Department of Microbiol and Molecular Medicine, University of Geneva
- Francesca Spadaro
- Istituto Superiore di Sanità, Confocal Microscopy Unit, Core Facilities
- Katia Stefanantoni
- Division of Rheumatology, Internal Medicine and Medical Specialties, University La Sapienza
- Nicoletta Iannace
- Division of Rheumatology, Internal Medicine and Medical Specialties, University La Sapienza
- Aleksandra Maria Dufour
- Immunology & Allergy and Immunology & Pathology, University Hospital and School of Medicine
- Mario Falchi
- Istituto Superiore di Sanità, National AIDS Center
- Manuela Bianco
- National Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)
- Elisabetta Botti
- Dermatology Unit, Department of Systems Medicine, University of Tor Vergata
- Luca Bianchi
- Dermatology Unit, Department of Systems Medicine, University of Tor Vergata
- Montserrat Alvarez
- Immunology & Allergy and Immunology & Pathology, University Hospital and School of Medicine
- Valeria Riccieri
- Division of Rheumatology, Internal Medicine and Medical Specialties, University La Sapienza
- Marie-Elise Truchetet
- Division of Rheumatology and immunoConcept, University Hospital
- Gerard C.L. Wong
- Department of Bioengineering, Department of Chemistry & Biochemistry, and California NanoSystems Institute, University of California
- Carlo Chizzolini
- Immunology & Allergy and Immunology & Pathology, University Hospital and School of Medicine
- Loredana Frasca
- National Center for Drug Research and Evaluation, Pharmacological research and experimental therapy UNIT, Istituto Superiore di Sanità (ISS)
- DOI
- https://doi.org/10.1038/s41467-019-09683-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.
