Oseltamivir Enhances Hippocampal Network Synchronization

Atsushi Usami; Takuya Sasaki; Nobuhiro Satoh; Takahiro Akiba; Satoshi Yokoshima; Tohru Fukuyama; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Norio Matsuki; Yuji Ikegaya

Journal of Pharmacological Sciences (Jan 2008)

Affiliations

Atsushi Usami: Laboratory of Chemical Pharmacology, Tokyo 113-0033, Japan
Takuya Sasaki: Laboratory of Chemical Pharmacology, Tokyo 113-0033, Japan
Nobuhiro Satoh: Laboratory of Synthetic Natural Products Chemistry, and Tokyo 113-0033, Japan
Takahiro Akiba: Laboratory of Synthetic Natural Products Chemistry, and Tokyo 113-0033, Japan
Satoshi Yokoshima: Laboratory of Synthetic Natural Products Chemistry, and Tokyo 113-0033, Japan
Tohru Fukuyama: Laboratory of Synthetic Natural Products Chemistry, and Tokyo 113-0033, Japan
Kenzo Yamatsugu: Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
Motomu Kanai: Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
Masakatsu Shibasaki: Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
Norio Matsuki: Laboratory of Chemical Pharmacology, Tokyo 113-0033, Japan
Yuji Ikegaya: Laboratory of Chemical Pharmacology, Tokyo 113-0033, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, 5 Sanbancho Chiyoda-ku, Tokyo 102-00075, Japan; Corresponding author (affiliation #1). [email protected]

Journal volume & issue: Vol. 106, no. 4
pp. 659 – 662

Abstract

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Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.Supplementary Fig. and movie: available only at http://dx.doi.org/10.1254/jphs.SC0070467 Keywords:: oseltamivir, functional multineuron calcium imaging, network excitability

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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