Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells

Wang Hexian; Fan Qiang; Zhang Longlong; Shi Danli; Wang Haibo; Wang Shoulian; Bian Bangjian

doi:10.1515/pteridines-2020-0020

Pteridines (Oct 2020)

Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells

Wang Hexian,
Fan Qiang,
Zhang Longlong,
Shi Danli,
Wang Haibo,
Wang Shoulian,
Bian Bangjian

Affiliations

Wang Hexian: Shanghai Jiao Tong University School of Medicine, Shanghai, China
Fan Qiang: Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Zhang Longlong: Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shi Danli: Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wang Haibo: Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wang Shoulian: Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Bian Bangjian: Department of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China

DOI: https://doi.org/10.1515/pteridines-2020-0020
Journal volume & issue: Vol. 31, no. 1
pp. 158 – 164

Abstract

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Objective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense. We studied the effects of folic acid on the apoptosis of breast cancer cells (MDA-MB-231) and on the activity of the PTEN/AKT/P53 signaling pathway in breast cancer cells.

Published in Pteridines

ISSN: 0933-4807 (Print); 2195-4720 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry: Crystallography
Website: https://www.degruyter.com/view/j/pteridines

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Abstract

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