Nature Communications (Nov 2016)
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
- Zhaohui Gu,
- Michelle Churchman,
- Kathryn Roberts,
- Yongjin Li,
- Yu Liu,
- Richard C. Harvey,
- Kelly McCastlain,
- Shalini C. Reshmi,
- Debbie Payne-Turner,
- Ilaria Iacobucci,
- Ying Shao,
- I-Ming Chen,
- Marcus Valentine,
- Deqing Pei,
- Karen L. Mungall,
- Andrew J. Mungall,
- Yussanne Ma,
- Richard Moore,
- Marco Marra,
- Eileen Stonerock,
- Julie M. Gastier-Foster,
- Meenakshi Devidas,
- Yunfeng Dai,
- Brent Wood,
- Michael Borowitz,
- Eric E. Larsen,
- Kelly Maloney,
- Leonard A. Mattano Jr,
- Anne Angiolillo,
- Wanda L. Salzer,
- Michael J. Burke,
- Francesca Gianni,
- Orietta Spinelli,
- Jerald P. Radich,
- Mark D. Minden,
- Anthony V. Moorman,
- Bella Patel,
- Adele K. Fielding,
- Jacob M. Rowe,
- Selina M. Luger,
- Ravi Bhatia,
- Ibrahim Aldoss,
- Stephen J. Forman,
- Jessica Kohlschmidt,
- Krzysztof Mrózek,
- Guido Marcucci,
- Clara D. Bloomfield,
- Wendy Stock,
- Steven Kornblau,
- Hagop M. Kantarjian,
- Marina Konopleva,
- Elisabeth Paietta,
- Cheryl L. Willman,
- Mignon L. Loh,
- Stephen P. Hunger,
- Charles G. Mullighan
Affiliations
- Zhaohui Gu
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- Michelle Churchman
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- Kathryn Roberts
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- Yongjin Li
- Department of Computational Biology, St Jude Children’s Research Hospital
- Yu Liu
- Department of Computational Biology, St Jude Children’s Research Hospital
- Richard C. Harvey
- University of New Mexico Cancer Center
- Kelly McCastlain
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- Shalini C. Reshmi
- The Research Institute, Nationwide Children’s Hospital
- Debbie Payne-Turner
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- Ilaria Iacobucci
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- Ying Shao
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- I-Ming Chen
- University of New Mexico Cancer Center
- Marcus Valentine
- Cytogenetic Shared Resource, St Jude Children’s Research Hospital
- Deqing Pei
- Department of Biostatistics, St Jude Children’s Research Hospital
- Karen L. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Andrew J. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Yussanne Ma
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Richard Moore
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Marco Marra
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Eileen Stonerock
- Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital
- Julie M. Gastier-Foster
- Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital
- Meenakshi Devidas
- Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida
- Yunfeng Dai
- Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida
- Brent Wood
- Department of Laboratory Medicine, University of Washington
- Michael Borowitz
- Department of Pathology, Johns Hopkins Medical Institutions
- Eric E. Larsen
- Maine Children’s Cancer Program
- Kelly Maloney
- Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children’s Hospital Colorado
- Leonard A. Mattano Jr
- HARP Pharma Consulting
- Anne Angiolillo
- Children's National Medical Center
- Wanda L. Salzer
- US Army Medical Research and Materiel Command
- Michael J. Burke
- Medical College of Wisconsin
- Francesca Gianni
- Department of Hematology and Bone Marrow Transplantation, Papa Giovanni XXIII Hospital
- Orietta Spinelli
- Department of Hematology and Bone Marrow Transplantation, Papa Giovanni XXIII Hospital
- Jerald P. Radich
- Fred Hutchinson Cancer Research Center
- Mark D. Minden
- Princess Margaret Cancer Centre, University Health Network
- Anthony V. Moorman
- Leukemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University
- Bella Patel
- Department of Haemato-Oncology, Barts Cancer Institute
- Adele K. Fielding
- Department of Hematology, UCL Cancer Institute
- Jacob M. Rowe
- Hematology, Shaare Zedek Medical Center
- Selina M. Luger
- Abramson Cancer Center, University of Pennsylvania
- Ravi Bhatia
- Division of Hematology and Oncology, Department of Medicine, The University of Alabama at Birmingham
- Ibrahim Aldoss
- Division of Hematology and Oncology, Department of Medicine, The University of Alabama at Birmingham
- Stephen J. Forman
- Gehr Family Center for Leukemia Research, City of Hope
- Jessica Kohlschmidt
- The Ohio State University Comprehensive Cancer Center
- Krzysztof Mrózek
- The Ohio State University Comprehensive Cancer Center
- Guido Marcucci
- Gehr Family Center for Leukemia Research, City of Hope
- Clara D. Bloomfield
- The Ohio State University Comprehensive Cancer Center
- Wendy Stock
- University of Chicago Medical Center
- Steven Kornblau
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Hagop M. Kantarjian
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Marina Konopleva
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Elisabeth Paietta
- Montefiore Medical Center North Division, Cancer Center
- Cheryl L. Willman
- University of New Mexico Cancer Center
- Mignon L. Loh
- Department of Pediatrics, Benioff Children’s Hospital
- Stephen P. Hunger
- Children’s Hospital of Philadelphia
- Charles G. Mullighan
- Department of Pathology and Hematological Malignancies Program, St Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/ncomms13331
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.
