Sublinear scaling of the cellular proteome with ploidy

G. Yahya; P. Menges; P. S. Amponsah; D. A. Ngandiri; D. Schulz; A. Wallek; N. Kulak; M. Mann; P. Cramer; V. Savage; M. Räschle; Z. Storchova

doi:10.1038/s41467-022-33904-7

Nature Communications (Oct 2022)

Sublinear scaling of the cellular proteome with ploidy

G. Yahya,
P. Menges,
P. S. Amponsah,
D. A. Ngandiri,
D. Schulz,
A. Wallek,
N. Kulak,
M. Mann,
P. Cramer,
V. Savage,
M. Räschle,
Z. Storchova

Affiliations

G. Yahya: Department of Molecular Genetics, TU Kaiserslautern
P. Menges: Department of Molecular Genetics, TU Kaiserslautern
P. S. Amponsah: Department of Molecular Genetics, TU Kaiserslautern
D. A. Ngandiri: Department of Molecular Genetics, TU Kaiserslautern
D. Schulz: Institute of Molecular Biology, University of Zurich
A. Wallek: Max Planck Institute of Biochemistry
N. Kulak: Max Planck Institute of Biochemistry
M. Mann: Max Planck Institute of Biochemistry
P. Cramer: Max Planck Institute for Multidisciplinary Sciences
V. Savage: Department of Biomathematics, University of California at Los Angeles
M. Räschle: Department of Molecular Genetics, TU Kaiserslautern
Z. Storchova: Department of Molecular Genetics, TU Kaiserslautern

DOI: https://doi.org/10.1038/s41467-022-33904-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Increasing the number of chromosome sets alters the physiology of cells. Here, the authors show that although the number of chromosome sets increases, the proteome does not scale linearly with the increasing ploidy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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