An in-vitro anti-inflammatory and anti-microbial essential on Ni(II), Cd(II) mixed ligand complexes by using 2,4-dinitrophenyl hydrazine and dimethylglyoxime

Abstract

The objective of the present work deals among synthesis as well as characterization of Ni(II), Cd(II) mixed ligand complex were derived from 2,4 di-nitrophenyl hydrazine and dimethyl glyoxime. The mixed ligand metal complexes were prepared via 2,4-dinitrophenyl hydrazine as well as dimethylglyoxime among Ni(II) and Cd(II) in molar radio (M:L1:L1) 1:1:1. CHNO analysis, conductivity measurement, PXRD, SEM, UV–visible, infrared spectrum, and magnetic susceptibility, thermal analysis were used to characterized the synthesized compounds. According to the study of the results, all of the metal complexes have octahedral geometry. The molar conductance value indicate that non-electrolytic character of compounds Ni(II), Cd(II). According to the powder X-ray diffraction (PXRD) patterns, all of the compounds are crystalline character. Moreover the Ni(II), Cd(II) complexes were very stable in terms of thermal stability. Metal complexes have been tested against Gram-positive (S. aureus, B. subtilis and A. niger) and Gram-negative (P. aeruginosa, E. coli and C. albicans) pathogenic bacteria as well as fungus. As a result, the metal complexes have reported strong antimicrobial efficiency. Conclusions: Furthermore, applications of metal compounds were tested for anti-inflammatory efficiency utilize egg albumin. Result shows that the activities of metal complexes are good.

Keywords

• Ni(II)-DNPH-DMG complex
• Cd(II)-DNPH-DMG complex
• Thermal analysis of mixed ligand metal complexes
• Antimicrobial
• Anti-inflammatory assay