Nature Communications (May 2018)
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
- Masaki Tsuchiya,
- Yuji Hara,
- Masaki Okuda,
- Karin Itoh,
- Ryotaro Nishioka,
- Akifumi Shiomi,
- Kohjiro Nagao,
- Masayuki Mori,
- Yasuo Mori,
- Junichi Ikenouchi,
- Ryo Suzuki,
- Motomu Tanaka,
- Tomohiko Ohwada,
- Junken Aoki,
- Motoi Kanagawa,
- Tatsushi Toda,
- Yosuke Nagata,
- Ryoichi Matsuda,
- Yasunori Takayama,
- Makoto Tominaga,
- Masato Umeda
Affiliations
- Masaki Tsuchiya
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Yuji Hara
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Masaki Okuda
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Karin Itoh
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Ryotaro Nishioka
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Akifumi Shiomi
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Kohjiro Nagao
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Masayuki Mori
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Yasuo Mori
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- Junichi Ikenouchi
- Department of Biology, Faculty of Sciences, Kyushu University
- Ryo Suzuki
- Institute for Integrated Cell-Material Sciences (WPI iCeMS), Kyoto University
- Motomu Tanaka
- Institute for Integrated Cell-Material Sciences (WPI iCeMS), Kyoto University
- Tomohiko Ohwada
- Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Junken Aoki
- Department of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
- Motoi Kanagawa
- Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine
- Tatsushi Toda
- Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo
- Yosuke Nagata
- Department of Life Science, Faculty of Science, Okayama University of Science
- Ryoichi Matsuda
- Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
- Yasunori Takayama
- Division of Cell Signaling, Okazaki Institute for Integrative Bioscience
- Makoto Tominaga
- Division of Cell Signaling, Okazaki Institute for Integrative Bioscience
- Masato Umeda
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-018-04436-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation.
