Nature Communications (Sep 2019)
GSTA4 mediates reduction of cisplatin ototoxicity in female mice
- Hyo-Jin Park,
- Mi-Jung Kim,
- Christina Rothenberger,
- Ashok Kumar,
- Edith M. Sampson,
- Dalian Ding,
- Chul Han,
- Karessa White,
- Kevin Boyd,
- Senthilvelan Manohar,
- Yong-Hwan Kim,
- Maria S. Ticsa,
- Aaron S. Gomez,
- Isabela Caicedo,
- Upal Bose,
- Paul J. Linser,
- Takuya Miyakawa,
- Masaru Tanokura,
- Thomas C. Foster,
- Richard Salvi,
- Shinichi Someya
Affiliations
- Hyo-Jin Park
- Department of Aging and Geriatric Research, University of Florida
- Mi-Jung Kim
- Department of Aging and Geriatric Research, University of Florida
- Christina Rothenberger
- Department of Aging and Geriatric Research, University of Florida
- Ashok Kumar
- Department of Neuroscience, University of Florida
- Edith M. Sampson
- Monoclonal Antibody Core, Interdisciplinary Center for Biotechnology Research, University of Florida
- Dalian Ding
- Center for Hearing and Deafness, State University of New York at Buffalo
- Chul Han
- Department of Aging and Geriatric Research, University of Florida
- Karessa White
- Department of Aging and Geriatric Research, University of Florida
- Kevin Boyd
- Department of Aging and Geriatric Research, University of Florida
- Senthilvelan Manohar
- Center for Hearing and Deafness, State University of New York at Buffalo
- Yong-Hwan Kim
- Department of Neurobiology, Barrow Neurological Institute
- Maria S. Ticsa
- Department of Aging and Geriatric Research, University of Florida
- Aaron S. Gomez
- Department of Aging and Geriatric Research, University of Florida
- Isabela Caicedo
- Department of Aging and Geriatric Research, University of Florida
- Upal Bose
- Department of Aging and Geriatric Research, University of Florida
- Paul J. Linser
- Whitney Laboratory, University of Florida
- Takuya Miyakawa
- Department of Applied Biological Chemistry, University of Tokyo
- Masaru Tanokura
- Department of Applied Biological Chemistry, University of Tokyo
- Thomas C. Foster
- Department of Neuroscience, University of Florida
- Richard Salvi
- Center for Hearing and Deafness, State University of New York at Buffalo
- Shinichi Someya
- Department of Aging and Geriatric Research, University of Florida
- DOI
- https://doi.org/10.1038/s41467-019-12073-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).
