The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression

Xiao-Min Luo; Sin Man Lam; Yuan Dong; Xiao-Juan Ma; Cen Yan; Yue-Jie Zhang; Yu Cao; Li Su; Guotao Lu; Jin-Kui Yang; Guanghou Shui; Ying-Mei Feng

doi:10.1038/s42003-022-04041-0

Communications Biology (Oct 2022)

The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression

Xiao-Min Luo,
Sin Man Lam,
Yuan Dong,
Xiao-Juan Ma,
Cen Yan,
Yue-Jie Zhang,
Yu Cao,
Li Su,
Guotao Lu,
Jin-Kui Yang,
Guanghou Shui,
Ying-Mei Feng

Affiliations

Xiao-Min Luo: Department of Science and Development, Beijing Youan hospital, Capital Medical University
Sin Man Lam: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Yuan Dong: Department of Science and Development, Beijing Youan hospital, Capital Medical University
Xiao-Juan Ma: Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital
Cen Yan: Department of Science and Development, Beijing Youan hospital, Capital Medical University
Yue-Jie Zhang: Department of Science and Development, Beijing Youan hospital, Capital Medical University
Yu Cao: Department of Science and Development, Beijing Youan hospital, Capital Medical University
Li Su: Neuroscience Research Institute, Peking University Center of Medical and Health Analysis, Peking University
Guotao Lu: Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University
Jin-Kui Yang: Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University
Guanghou Shui: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Ying-Mei Feng: Department of Science and Development, Beijing Youan hospital, Capital Medical University

DOI: https://doi.org/10.1038/s42003-022-04041-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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Metabolomics analysis reveals that inosine monophosphate, a purine metabolite, promotes myelopoiesis and contributes to severe acute pancreatitis in db/db mice.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal