Detection of Mannose Binding Lectin (MBL) -54 G/A Polymorphism in Preterm Labor in Hilla Province/Iraq

Abstract

To analyzes the association between Mannose binding lectin MBL gene and preterm labor, DNA was obtained from peripheral blood of 150 aborted women patients diagnosed as preterm labor and 150 healthy individual have no previous preterm history was extracted. Mannose binding lectin gene was genotyped by PCR-RFLP (Polymerase Chain Reaction – Restriction Fragment Length Polymorphism) method. The data were analyzed by odd ratio (OR) calculation with confidence intervals (CI 95%) and chi square x 2 results were statically analysis. Statistical significant were sent as p value ≤0.05. The allelic frequency between gene and preterm labor group was (94.5) in control compared with (70.7) in patients with significant differences. The homozygous were found to be more than heterozygous (32.3) whereas homozygous AA (43.4) and GG (33.3) with significant differences this work is considered the first study for understanding the correlation between Preterm birth and mannose protein level in Iraq

Keywords

• mannose binding lectin
• polymorphism
• preterm labor