An analysis of the risk factors of preeclampsia and prediction based on combined biochemical indexes

Abstract

This study aims to investigate the risk factors and the joint biochemical indicators predictive value for preeclampsia. Related factors and biochemical indicators were investigated in 558 patients with preeclampsia and 435 normal pregnant women. Multiplicity analysis was performed by logistic regression. The predictive value of the biochemical index and joint biochemical indicators for predicting the incidence of pregnant women preeclampsia were analyzed by ROC curve. A progestation BMI of >24 kg/m2 (OR = 5.412, 95% CI: 1.169–9.447), hypertension history (OR = 7.487, 95% CI: 2.541–11.247) and advanced age (>35 years old, OR = 6.321, 95% CI: 3.142–20.342) are risk factors for preeclampsia. Tumor necrosis factor-α and plasma protein-A are valuable for preeclampsia prediction. The predictive success of preeclampsia could be improved by clinical risk factors associated with biochemical indicators detection.

Keywords

• Preeclampsia
• Risk factors
• Biochemical indexes
• Prediction analysis