Nature Communications (May 2017)

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

  • Fabio Iannelli,
  • Alessandro Galbiati,
  • Ilaria Capozzo,
  • Quan Nguyen,
  • Brian Magnuson,
  • Flavia Michelini,
  • Giuseppina D’Alessandro,
  • Matteo Cabrini,
  • Marco Roncador,
  • Sofia Francia,
  • Nicola Crosetto,
  • Mats Ljungman,
  • Piero Carninci,
  • Fabrizio d’Adda di Fagagna

DOI
https://doi.org/10.1038/ncomms15656
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.