Diabetes, Metabolic Syndrome and Obesity (Nov 2022)
Analysis of the Outcomes of 73 Patients with Exogenous Positive Insulin Anti-Body
Abstract
Dan Yao,1 Jian-Ping Chu,2 Zhi-Yan Chen1 1Department of Endocrinology, Xiangshan Hospital of TCM Medical and Health Group, Ningbo, 315700, People’s Republic of China; 2Department of Endocrinology, Ningbo City First Hospital, Ningbo, 315000, People’s Republic of ChinaCorrespondence: Jian-Ping Chu, Department of Endocrinology, Ningbo first hospital, No.59 Liuting Street, Ningbo, Zhejiang Province, 315000, People’s Republic of China, Tel/Fax +86-574-87089141, Email [email protected]: This study aimed to discuss adjusting the treatment plan for patients with type 2 diabetes mellitus (T2DM) who are positive for exogenous insulin antibody (IA). The outcome of patients who are IA-positive with an adjusted treatment plan was considered.Methods: The treatment plan for patients with IA-positive T2DM was adjusted to oral medication or long-acting insulin + oral medication. Insulin antibody, C-peptide, and insulin were re-examined before treatment and at 1, 3, 6, 12, 18, and 24 months after treatment. The time of IA-negative seroconversion and its indexes, including blood glucose, C-peptide, and insulin, were recorded and analyzed.Results: After adjusting the treatment plan for 2 years, in 73 patients, 57 had IA-negative seroconversion, and 16 had positive IA. The blood glucose, C-peptide, insulin, glycosylated hemoglobin (HbA1c), and the daily dose of insulin in the seroconversion group and the non-seroconversion group decreased compared with before the adjustment of the treatment plan (P < 0.05). The negative seroconversion rate within 2 years was related to the insulin concentration before treatment.Conclusion: Patients with IA-positive T2DM need to adjust their treatment plans in time. Even if IA does not turn negative within 2 years after adjusting the treatment plan, the levels of blood glucose, C-peptide, insulin, and HbA1c along with the insulin dosage would be significantly improved, which can benefit patients. The higher the fasting insulin and 2-hour insulin values before adjusting the treatment plan, the longer the time required for IA to turn negative.Keywords: insulin antibody, diabetes, type 2, negative seroconversion rate
