The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine

Laura Iop; Eleonora Dal Sasso; Leonardo Schirone; Maurizio Forte; Mariangela Peruzzi; Elena Cavarretta; Silvia Palmerio; Gino Gerosa; Sebastiano Sciarretta; Giacomo Frati

doi:10.1155/2017/7953486

Mediators of Inflammation (Jan 2017)

The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine

Laura Iop,
Eleonora Dal Sasso,
Leonardo Schirone,
Maurizio Forte,
Mariangela Peruzzi,
Elena Cavarretta,
Silvia Palmerio,
Gino Gerosa,
Sebastiano Sciarretta,
Giacomo Frati

Affiliations

Laura Iop: Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua and Venetian Institute of Molecular Medicine, Padua, Italy
Eleonora Dal Sasso: Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua and Venetian Institute of Molecular Medicine, Padua, Italy
Leonardo Schirone: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
Maurizio Forte: IRCCS Neuromed, Pozzilli, Italy
Mariangela Peruzzi: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
Elena Cavarretta: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
Silvia Palmerio: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
Gino Gerosa: Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua and Venetian Institute of Molecular Medicine, Padua, Italy
Sebastiano Sciarretta: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
Giacomo Frati: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy

DOI: https://doi.org/10.1155/2017/7953486
Journal volume & issue: Vol. 2017

Abstract

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Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress. At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. In this review, we explore the intrinsic and extrinsic causes of cellular senescence and their role in the onset of these cardiovascular pathologies. Additionally, we dissect the effects of aging on the cardiac endogenous and exogenous reservoirs of stem cells. Finally, we offer an overview on the strategies of regenerative medicine that have been advanced in the quest for heart rejuvenation.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

About the journal