Nature Communications (Oct 2018)
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
Abstract
Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient in mammary cells.