Nature Communications (Apr 2020)
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
- Simona P. Pfister,
- Olivier P. Schären,
- Luca Beldi,
- Andrea Printz,
- Matheus D. Notter,
- Mohana Mukherjee,
- Hai Li,
- Julien P. Limenitakis,
- Joel P. Werren,
- Disha Tandon,
- Miguelangel Cuenca,
- Stefanie Hagemann,
- Stephanie S. Uster,
- Miguel A. Terrazos,
- Mercedes Gomez de Agüero,
- Christian M. Schürch,
- Fernanda M. Coelho,
- Roy Curtiss,
- Emma Slack,
- Maria L. Balmer,
- Siegfried Hapfelmeier
Affiliations
- Simona P. Pfister
- Institute for Infectious Diseases, University of Bern
- Olivier P. Schären
- Institute for Infectious Diseases, University of Bern
- Luca Beldi
- Institute for Infectious Diseases, University of Bern
- Andrea Printz
- Institute for Infectious Diseases, University of Bern
- Matheus D. Notter
- Institute for Infectious Diseases, University of Bern
- Mohana Mukherjee
- Institute for Infectious Diseases, University of Bern
- Hai Li
- Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM) Inselspital
- Julien P. Limenitakis
- Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM) Inselspital
- Joel P. Werren
- Institute for Infectious Diseases, University of Bern
- Disha Tandon
- Institute for Infectious Diseases, University of Bern
- Miguelangel Cuenca
- Institute for Infectious Diseases, University of Bern
- Stefanie Hagemann
- Institute for Infectious Diseases, University of Bern
- Stephanie S. Uster
- Institute for Infectious Diseases, University of Bern
- Miguel A. Terrazos
- Institute for Infectious Diseases, University of Bern
- Mercedes Gomez de Agüero
- Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM) Inselspital
- Christian M. Schürch
- Institute of Pathology, University of Bern
- Fernanda M. Coelho
- Institute for Infectious Diseases, University of Bern
- Roy Curtiss
- Biodesign Institute, Arizona State University
- Emma Slack
- Institute for Food, Nutrition and Health, D-HEST
- Maria L. Balmer
- Department of Biomedicine, Immunobiology, University of Basel
- Siegfried Hapfelmeier
- Institute for Infectious Diseases, University of Bern
- DOI
- https://doi.org/10.1038/s41467-020-15891-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Virulent pathogens generally induce a stronger mucosal immunity than avirulent strains, but whether the associated inflammation is necessary for this is unclear. Here, using auxotrophic Salmonella enterica, the authors show that virulence factor function determines induction of protective IgA.
