Clinical Ophthalmology (Sep 2018)
Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
Abstract
Shwu-Jiuan Sheu,1,2 Ying-Yen Lee,1 Yu-Harn Horng,1 Huey-Shyan Lin,3 Wei-Yu Lai,1 Chui-Lien Tsen1 1Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan Purpose: To investigate optical coherence tomography (OCT) characteristics in diabetic macular edema (DME) over time and after treatment. Patients and methods: OCT morphological features in DME eyes treated with ranibizumab with at least 1 year of follow-up were retrospectively analyzed. Results: Thirty-five eyes were included. From baseline to Month 12, mean visual gain was 7.2±13.6 letters and mean central retinal thickness reduction was 61.9±121.8 µm. Fovea-involving ellipsoid zone (EZ) disruption was significantly associated with final vision of <70 letters. Subretinal fluid at baseline was present only in eyes naïve to previous intravitreal pharmacotherapy and was related to better visual gain and fewer injections. Treatment-naïve eyes had shorter DME duration and less EZ damage. Conclusion: DME characteristics on OCT may change over time or after treatment. Subretinal fluid may be associated with earlier change and less EZ damage in DME. Keywords: diabetic macular edema, optical coherence tomography, OCT, subretinal fluid, SRF, vascular endothelial growth factor, VEGF
