Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

Boguang Yang; Kongchang Wei; Claudia Loebel; Kunyu Zhang; Qian Feng; Rui Li; Siu Hong Dexter Wong; Xiayi Xu; Chunhon Lau; Xiaoyu Chen; Pengchao Zhao; Chao Yin; Jason A. Burdick; Yi Wang; Liming Bian

doi:10.1038/s41467-021-23120-0

Nature Communications (Jun 2021)

Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

Boguang Yang,
Kongchang Wei,
Claudia Loebel,
Kunyu Zhang,
Qian Feng,
Rui Li,
Siu Hong Dexter Wong,
Xiayi Xu,
Chunhon Lau,
Xiaoyu Chen,
Pengchao Zhao,
Chao Yin,
Jason A. Burdick,
Yi Wang,
Liming Bian

Affiliations

Boguang Yang: Department of Biomedical Engineering, The Chinese University of Hong Kong
Kongchang Wei: Department of Biomedical Engineering, The Chinese University of Hong Kong
Claudia Loebel: Department of Bioengineering, University of Pennsylvania
Kunyu Zhang: Department of Biomedical Engineering, The Chinese University of Hong Kong
Qian Feng: Department of Biomedical Engineering, The Chinese University of Hong Kong
Rui Li: Department of Biomedical Engineering, The Chinese University of Hong Kong
Siu Hong Dexter Wong: Department of Biomedical Engineering, The Chinese University of Hong Kong
Xiayi Xu: Department of Biomedical Engineering, The Chinese University of Hong Kong
Chunhon Lau: Department of Physics, The Chinese University of Hong Kong
Xiaoyu Chen: Department of Biomedical Engineering, The Chinese University of Hong Kong
Pengchao Zhao: Department of Biomedical Engineering, The Chinese University of Hong Kong
Chao Yin: Department of Biomedical Engineering, The Chinese University of Hong Kong
Jason A. Burdick: Department of Bioengineering, University of Pennsylvania
Yi Wang: Department of Physics, The Chinese University of Hong Kong
Liming Bian: Department of Biomedical Engineering, The Chinese University of Hong Kong

DOI: https://doi.org/10.1038/s41467-021-23120-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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3D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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