Cell Reports (Sep 2023)

A neuron-specific interaction between Alzheimer’s disease risk factors SORL1, APOE, and CLU

  • Pranav Preman,
  • Amaia M. Arranz

Journal volume & issue
Vol. 42, no. 9
p. 113129

Abstract

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Lee et al.1 report that loss of the Alzheimer’s disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Aβ levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.

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