Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Abstract

Molecular fragments are useful tools in drug-discovery but they might be hard to identify due to their weak affinity to the targets. Here, the authors use a protein-templated assembly to design high affinity inhibitors of Coxsackie virus 3C protease, a pharmacological target against enteroviral infections.