Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice

Young Woo Noh; Chaehyun Yook; Jaeseung Kang; Soowon Lee; Yeonghyeon Kim; Esther Yang; Hyun Kim; Eunjoon Kim

doi:10.1038/s42003-022-03813-y

Communications Biology (Aug 2022)

Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice

Young Woo Noh,
Chaehyun Yook,
Jaeseung Kang,
Soowon Lee,
Yeonghyeon Kim,
Esther Yang,
Hyun Kim,
Eunjoon Kim

Affiliations

Young Woo Noh: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Chaehyun Yook: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
Jaeseung Kang: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
Soowon Lee: Graduate School of Medical Science and Engineering, KAIST
Yeonghyeon Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
Esther Yang: Department of Anatomy and BK21 Graduate Program, Biomedical Sciences, College of Medicine, Korea University
Hyun Kim: Department of Anatomy and BK21 Graduate Program, Biomedical Sciences, College of Medicine, Korea University
Eunjoon Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s42003-022-03813-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Re-expression of the insulin receptor substrate p53 (IRSp53) in adult IRSp53-mutant mice rescues behavioral and synaptic deficits, suggesting that adult re-expression may hold future therapeutic potential.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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