mSystems (Aug 2021)

Association between Human Genetic Variants and the Vaginal Bacteriome of Pregnant Women

  • Wei Fan,
  • Hui Kan,
  • Hai-Yan Liu,
  • Tian-Lei Wang,
  • Yi-Ning He,
  • Miao Zhang,
  • Ya-Xin Li,
  • Yi-Jie Li,
  • Wei Meng,
  • Qing Li,
  • An-Qun Hu,
  • Ying-Jie Zheng

DOI
https://doi.org/10.1128/mSystems.00158-21
Journal volume & issue
Vol. 6, no. 4

Abstract

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Knowledge about the influence of host genetics on the vaginal bacteriome in pregnancy is still limited. Although a number of environmental and behavioral factors may exert influences on the structure of vaginal bacterial communities, the vaginal bacteriome often undergoes a relatively fixed transition to a more stable and less diverse state as the menstrual cycle stops, which raises questions on the effects of human genetics.