Frontiers in Veterinary Science (Jun 2021)
The Effect of the Antimicrobial Peptide Plectasin on the Growth Performance, Intestinal Health, and Immune Function of Yellow-Feathered Chickens
- Xinheng Zhang,
- Xinheng Zhang,
- Xinheng Zhang,
- Xinheng Zhang,
- Qiqi Zhao,
- Qiqi Zhao,
- Qiqi Zhao,
- Qiqi Zhao,
- Lijun Wen,
- Che Wu,
- Che Wu,
- Ziqi Yao,
- Ziqi Yao,
- Ziqi Yao,
- Ziqi Yao,
- Zhuanqiang Yan,
- Ruoying Li,
- Ruoying Li,
- Ruoying Li,
- Ruoying Li,
- Liyi Chen,
- Liyi Chen,
- Liyi Chen,
- Liyi Chen,
- Feiyang Chen,
- Feiyang Chen,
- Zi Xie,
- Zi Xie,
- Zi Xie,
- Feng Chen,
- Feng Chen,
- Feng Chen,
- Feng Chen,
- Qingmei Xie,
- Qingmei Xie,
- Qingmei Xie,
- Qingmei Xie
Affiliations
- Xinheng Zhang
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Xinheng Zhang
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Xinheng Zhang
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Xinheng Zhang
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Qiqi Zhao
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Qiqi Zhao
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Qiqi Zhao
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Qiqi Zhao
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Lijun Wen
- Guangdong Hinabiotech Co., Ltd, Guangzhou, China
- Che Wu
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Che Wu
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Ziqi Yao
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Ziqi Yao
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Ziqi Yao
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Ziqi Yao
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Zhuanqiang Yan
- Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control, Wen's Foodstuff Group Co., Ltd, Yunfu, China
- Ruoying Li
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Ruoying Li
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Ruoying Li
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Ruoying Li
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Liyi Chen
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Liyi Chen
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Liyi Chen
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Liyi Chen
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Feiyang Chen
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Feiyang Chen
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Zi Xie
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Zi Xie
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Zi Xie
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Feng Chen
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Feng Chen
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Feng Chen
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Feng Chen
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Qingmei Xie
- Lingnan Guangdong Laboratory of Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China
- Qingmei Xie
- Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding & Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China
- Qingmei Xie
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Qingmei Xie
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- DOI
- https://doi.org/10.3389/fvets.2021.688611
- Journal volume & issue
-
Vol. 8
Abstract
The goal of the study was to test the effects of an antibiotic substitute, plectasin, on the growth performance, immune function, intestinal morphology and structure, intestinal microflora, ileal mucosal layer construction and tight junctions, ileal immune-related cytokines, and blood biochemical indices of yellow-feathered chickens. A total of 1,500 one-day-old yellow-feathered chicks were randomly divided into four dietary treatment groups with five replicates in each group and 75 yellow-feathered chicks in each replication, as follows: basal diet (group A); basal diet supplemented with 10 mg enramycin/kg of diet (group B), basal diet supplemented with 100 mg plectasin/kg of diet (group C), and basal diet supplemented with 200 mg plectasin/kg of diet (group D). It was found that the dietary antimicrobial peptide plectasin could improve the ADG and had better F/G for the overall period of 1–63 days. Dietary plectasin can enhance H9N2 avian influenza virus (AIV) and Newcastle disease virus (NDV) antibody levels of yellow-feathered chickens at 21, and 35 days of age. Dietary plectasin can enhance the intestine structure, inhibit Escherichia coli and proinflammatory cytokines in the ileum, and ameliorate the blood biochemical indices of yellow-feathered chickens at 21 days of age. This study indicates that the antimicrobial peptide plectasin has beneficial effects on the growth performance, intestinal health and immune function of yellow-feathered chickens.
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