Preparation of α,β-Unsaturated Ketones Bearing a Trifluoromethyl Group and Their Application in Organic Synthesis

Abstract

The approaches to the synthesis of α,β-unsaturated CF3-containing ketones and their use in organic chemistry are reviewed. The synthetic applications of these ketones are discussed. The formation of 4-, 5-, 6- and 7-membered heterocycles bearing a CF3 group based on reactions of α,β-unsaturated CF3-containing ketones with different nucleophiles are discussed.

Keywords

• α
• β-Unsaturated trifluoromethyl ketones
• CF3-containing heterocycles
• trifluoroacetylation
• synthesis
• review