Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

Balázs Decsi; Réka Krammer; Kristóf Hegedűs; Ferenc Ender; Benjámin Gyarmati; András Szilágyi; Róbert Tőtős; Gabriel Katona; Csaba Paizs; György  T. Balogh; László Poppe; Diána Balogh-Weiser

doi:10.3390/mi10100668

Micromachines (Oct 2019)

Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

Balázs Decsi,
Réka Krammer,
Kristóf Hegedűs,
Ferenc Ender,
Benjámin Gyarmati,
András Szilágyi,
Róbert Tőtős,
Gabriel Katona,
Csaba Paizs,
György T. Balogh,
László Poppe,
Diána Balogh-Weiser

Affiliations

Balázs Decsi: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Réka Krammer: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Kristóf Hegedűs: SpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, Hungary
Ferenc Ender: SpinSplit Llc., 1082 Budapest, Leonardo da Vinci u. 43b, Hungary
Benjámin Gyarmati: Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
András Szilágyi: Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Róbert Tőtős: Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
Gabriel Katona: Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
Csaba Paizs: Biocatalysis and Biotransformation Research Centre, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University of Cluj-Napoca, 400028 Cluj-Napoca, Arany Janos street 11, Romania
György T. Balogh: Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, 1111 Budapest, Budafoki út 8, Hungary
László Poppe: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary
Diána Balogh-Weiser: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Műegyetem rkp. 3, Hungary

DOI: https://doi.org/10.3390/mi10100668
Journal volume & issue: Vol. 10, no. 10
p. 668

Abstract

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Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).

Published in Micromachines

ISSN: 2072-666X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Mechanical engineering and machinery
Website: https://www.mdpi.com/journal/micromachines

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